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.... Webinar
Kiskinis CBW - modeling pediatric epilepsy Coffee Break Webinar: Modeling pediatric epilepsy with iPSC-based technologies 

One third of all children with epilepsy fail to respond to currently available medication. The primary challenge of epilepsy research is the lack of model systems that effectively mirror what goes wrong in human patients. In this webinar, Dr. Evangelos Kiskinis (Northwestern University), demonstrates how patient-specific neurons in vitro recapitulate the neural firing patterns observed in patient EEGs in vivo. Using this platform Dr. Kiskinis hopes to be able to predict what drug would work best for each patient.

Grab a cup of coffee and enjoy the webinar here. 

.... Publications
Neuron Journal Cover Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

Explore how Axion Maestro MEA technology recordings of CRISPR/Cas-9-based gene edited hiPSC neurons showed an abnormal increase in neuronal activity in response to chronic depolarization.
 
Sohn P, Huang C, et al. (2019). Neuron. 
 
Read the full article here. 
Brain Journal Cover A causal role for TRESK loss of function in migraine mechanisms

Discover how Maestro technology aided researchers investigation TRESK function in human nociceptive neurons from induced pluripotent stem cell-based models.
 
Pettingill P, Weir G, et al. (2019). Brain. 
 
Read the full article here. 
Nature Scientific Reports Journal Cover Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

Axion's Maestro MEA mutiwell technology enabled researchers to study neuron-astrocyte crosstalk and human brain disease in a dish.
 
Hyvarinen T, Hagman S, et al. (2019). Scientific Reports. 
 
Read the full article here. 
Nature Communications Journal Cover TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Learn how researchers used Axion Maestro MEA technology to investigate a pro-arrythmia state in HADA-deficiect hiPSC-derived cardiomyoctyes.
 
Miklas J, Clark E, et al. (2019). Nature Communications. 
 
Read the full article here. 
.... Upcoming Events
Cell Therapy Analytical Development Summit 2019 Cell Therapy Analytical Development Summit (Dec 10-12 | Boston, MA)

Visit Axion’s booth to see how Axion’s new Maestro Z platform is being used to test the potency of T cells in real-time, label-free kill assays.

 ... AxIS Tips
Axis Software Tips Accelerate playback or recording in AxIS Navigator

In AxIS Navigator, when playing back a file, right-click the Play button and select Accelerate Playback to replay the file faster than real time. When analyzing a file after applying the appropriate configuration, right-click the Record Button and select Accelerate Recording to replay the file and save the analysis file(s) faster than real time.

 

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