Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging
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Derivation of peripheral nociceptive, mechanoreceptive, and proprioceptive sensory neurons from the same culture of human pluripotent stem cells
The authors developed a protocol for deriving three sensory neuron subtypes: nociceptors, mechanoreceptors, and proprioceptors from human pluripotent stem cells. The Maestro platform assessed the electrical activity and functional response of the derived subtypes.
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A human stem cell‑derived test system for agents modifying neuronal N‑methyl‑d‑aspartate‑type glutamate receptor Ca2+‑signalling
In order to assess functional neuronal receptors in vitro the authors developed a pluripotent stem cell-derived neural culture capable of forming functional neural networks on Axion's multiwell MEA system.
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Investigation into the Role of ERK in Tyrosine Kinase Inhibitor-Induced Neuropathy
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Multifunctional Cell Therapies Summit (May 4-6)
Be sure to visit our virtual booth to learn about our high throughput Maestro ZHT platform for your in vitro potency and cell therapy assays.
Allogeneic Cell Therapies Summit (May 17-19)
Stop by our virtual booth and discover how researchers are using our Maestro Z and ZHT assay systems to track immune cell mediated cancer cell killing label-free and in real time.
Oncolytic Viruses Symposium (May 25)
Discover how the Maestro Z and ZHT platforms can record your in vitro assay label-free and in real time.
Time referencing either subtracts (Correction) or divides by (Normalization) the impedance value at the Time Reference Cursor on a well-by-well basis. Time referencing is most often used in dosing experiments to remove the variability before the dosing event and quantify the subsequent changes caused by dosing alone. When the Time Reference drop-down is set in the Impedance Menu to Correction or Normalization, the Time Reference Cursor is visible but dashed, indicating that no time referencing is being applied. To turn on time referencing, drag the Time Reference Cursor to the desired time point and click on the cursor.
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Lumos is a snap to start working with right off the bat. The software makes it really easy to start controlling different lights with different colors and pulse patterns within a couple minutes. By hooking up a light meter under the plate to an oscilloscope, I could see that the light is controlled very precisely (microsecond precision) with really high max intensity reaching the bottom of the well. Perhaps the best thing for me was that the plate/lid design prevents light targeted to one well from bleeding over or reaching adjacent wells, which is pretty important for experiments.
Eric Brown |