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Targeted stabilization of Munc18-1 function via pharmacological chaperones

In this paper, the authors identified two structure-based drug designs that bind to wild-type and mutant Munc18-1 and revert the neuronal dysfunction as a potential targeted treatment against severe pediatric encephalopathies.
Abramov D, Guiberson NGL, et al. (2020). EMBO Molecular Medicine. 
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Effects of cryopreservation on human induced pluripotent stem cell-derived cardiomyocytes for assessing drug safety response profiles

In this study, the authors investigated the differences between fresh (non-cryopreserved) hiPSC-CMs and hiPSC-CMs recovered from cryopreservation by characterizing and comparing their genetic makeup, electrical function, and response to various cardiotoxic drugs.

Zhang JZ, Belbachir N, et al. (2021). Stem Cell Reports. 
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Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

In this paper, the Maestro platform was used to measure the functional properties of iPSC-derived neurons modeling neonatal epileptic encephalopathy.

Simkin D, Marshall KA, et al. (2021). eLife.
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Comparison of acute effects of neurotoxic compounds on network activity in human and rodent neural cultures

The authors generated excitatory and inhibitory hiPSC-derived neurons independently and co-cultured the neurons with primary human astrocytes. The resulting co-cultures exhibited neural activity and formed synchronized neural network activity recorded on Axion's MEA platform.
Saavedra L, Wallace K, et al. (2021). Toxicological Sciences. 
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Upcoming Events

Society of Toxicology Virtual (March 12-26)

Be sure to visit our virtual booth to see how Maestro research is impacting the field of toxicology and learn more about the world's most advanced MEA and impedance platform.


AxIS Tips

Online Cell Plating Calculator

Ever feel like you are spending too much time trying to figure out your cell plating values?

We have taken care of the math for you with our new online cell plating calculator.

Curious? Watch this video to learn how it works.

Calculate your cell plating

Customer Review

Orange Quote
The user-friendly software is very nice and visualizes neural activity from multiple wells in real-time, and it is intuitive.  Our lab members can easily operate and smoothly conduct experiments with drug and electrical stimulations  Since the temperature and CO2 environments are well maintained, long-term continuous measurement is possible.  In addition, the MEA plates delivered are well managed, and customer support is very good.

Dr. Ikuro Suzuki
Tohoku Institute of Technology, Japan


Easy to use, high throughput electrophysiological platform.


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