Axion Biosystems    

Publications

SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function

This study demonstrates that SARS-CoV-2 readily infects and replicates within human pluripotent stem cell cardiomyoctyes (hPSC-CMs), showing progressive impairment in both electrophysiological and contractile properties.
 
Marchiano S, Hsiang TY, et al. (2021). Stem Cell Reports. 
 
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Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing

Specific genes in human induced pluripotent stem cell-derived cardiomyocytes were evaluated to determine the role in the sinoatrial node. Axion's Maestro MEA platform was used to assess the changes in cardiac beat rate.

Dandan L, Jinfeng X, et al. (2021). Nature Communications. 
 
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Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids

A compliant, multifunctional 3D electronic interface to surround a bioengineered brain organoid was developed. With a custom connection to the Maestro Pro, the authors were able to record the functional neuronal activity from the surface of the organoid.

Park Y, Franz CK, et al. (2021). Science Advances.
 
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The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease

Spontaneous electrical firing was recorded on Axion's multielectrode array platform to compare control and ATP7a patient derived iPSC-motor neurons. Read this study to understand how copper homeostasis impacts neural network excitability.
 
Bakkara N, Starra A, et al. (2021). Neurobiology of Disease. 
 
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Upcoming Events

Society of Toxicology Virtual (March 12-26)

Be sure to visit our virtual booth to see how Maestro research is impacting the field of toxicology and learn more about the world's most advanced MEA and impedance platform.

 

Innate Killer Summit (March 23-25)

Stop by our virtual booth and discover how researchers are using our Maestro Z and ZHT assay systems to track NK cell mediated cancer cell killing label-free and in real time.

 

AxIS Tips

Cell Plating Calculator
Insert Templates in Plate Map Setup

In AxIS Z, the Plate Map Setup panel is used to set up Well Groups for each treatment combination, assign controls, and assign each Well Group to the plate map. Plate map templates are included to provide recommendations for Well Groups, including control types, for a specific assay or application. Plate map templates may be loaded by selecting the Load Template option from the Well Groups drop-down menu. Pre-designed templates for specific applications such as Immuno-oncology, GPCR, Cytotoxicity, and Cell Growth are provided. Templates below the horizontal line in the menu (Example Immuno-oncology, Well-by-well, etc.) provide example plate map designs that include well assignments in the Plate Map.

Customer Review

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Our Maestro Pro MEA has proven to be a fantastic tool in our research so far. The instrument itself is high quality and user-friendly and the software has a coherent interface that makes operating the instrument and data analysis easy to learn. The Axion team has been incredibly available and helpful whenever we hit a snag or have questions - they have even been proactive to reach out to us with information they think might be useful for our applications. We have only scratched the surface with the capabilities of the Maestro Pro in our applications and we have exciting plans of incorporating it more broadly into our research and services moving forward.

Jacquelyn Webb
Thermo Fisher Scientific, USA

 

Easy to use, great results, and promising future directions!

 

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