Axion Biosystems    


Modeling Sporadic Alzheimer’s Disease in Human Brain Organoids under Serum Exposure

Discover how the Maestro Pro recorded activity from the hiPSC-derived brain organoids modeling AD and showed a significant difference in spike, burst and synchrony activity with different serum exposures.
Chen X, Sun G, et al. (2021). Advanced Science. 
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Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

In this study, the Maestro platform helped characterize 53 iPSC lines derived from Alzheimer's Disease patients as a resource for researchers looking to understand its pathological pathways.

Lagomarsino VN, Pearse RV, et al. (2021). Neuron. 
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An Electrophysiological and Pharmacological Study of the Properties of Human iPSC-Derived Neurons for Drug Discovery

The Maestro Pro MEA platform was used to characterize spontaneous spiking activity in iCell GABAneurons(R) over the course of a month.

Halliwell RF, Salmanzadeh H, et al. (2021). Cells.
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miR-29a and the PTEN–GSK3β axis are involved in aluminum-induced damage to primary hippocampal neuronal networks

In this study, the authors used primary mouse hippocampal neurons in Axion's MEA system to model aluminum-induced damage characterized by significant inhibition of electrical spike activity.
Cooper B, Guerrelli D, and Posnack N, et al. (2021). Ecotoxicology and Environmental Safety. 
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Studying Brains on a Lab Bench 

Microelectrode array technology enables neuroscientists to investigate neural networks from the comfort of their lab bench; here, James Ross discusses its implications for understanding neurological diseasess.

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Probing Models of Neurological Disease in a Dish Using Multielectrode Arrays 

Researchers are opening new doors to model and treat neurological diseases using induced pluripotent stem cell-derived neurons. See how they are being used to recapitulate diseases such as ALS and epilepsy.

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Upcoming Events

World Bispecific Summit (Sept 29-Oct 1)

Discover how the Maestro Z and ZHT platforms can be used to assess immunotherapies in vitro.


Immuno Series UK (Oct 13-15)

Stop by in person or virtually and learn how the Maestro impedance platform can support your immunotherapy assays.


Cells UK (Oct 28-29)

Discover how the Maestro systems allow you to capture the functionality of your cells label-free and in real time.


AxIS Tips

Axis z Tips
Analysis Endpoints in AxIS-Z

The Endpoint drop-down selects the endpoint plotted by the Impedance Map and Endpoint Plot. Endpoints are calculated for each replicate.  Individual well values are displayed on the Impedance Map; and then averaged across replicate wells for the Endpoint Plot. The following endpoints are available:

  • At Cursor – Impedance value at the Endpoint cursor time point.
  • Maximum – Maximum impedance value between the two cursors, Endpoint Start and Endpoint End.
  • Minimum – Minimum impedance value between the two cursors, Endpoint Start and Endpoint End.
  • Area Under The Curve – Net area under the impedance curve between the Endpoint Start and Endpoint End cursors.
  • Kill Time 50 – The time from the Endpoint Start Cursor (e.g. the dosing time) to the point of 50% cytolysis.

Customer Review

Orange Quote
Positive impact in our lab. User-friendly software.

Robert Hein
University of Oxford, UK



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