Axion Biosystems    


>> Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer’s disease
A multiplatform study including transgenic mouse models and postmortem brain slices reveals that MeCP2-mediated dysregulation is associated with cognitive abnormalities and may be a promising therapeutic target for Alzheimer’s disease.
Lee S, Kim TK, et al. (2022). Theranostics. 
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>> IDH mutated gliomas promote epileptogenesis through D-2-hydroxyglutarate dependent mTOR hyperactivation
Scientists used neuron-glial rat cortical cell culture models and human cortical tissue from patients with IDH-mutant gliomas to demonstrate how D-2-hydroxyglutarate (D-2-HG) alters metabolic profiles and promotes seizure activity.
Mortazavi A, Fayed I, et al. (2022). Neuro-Oncology. 
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>> Impact of high-dose irradiation on human iPSC-derived cardiomyocytes using multi-electrode arrays: implications for the antiarrhythmic effects of cardiac radioablation
Researchers used human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) to examine the immediate and reversible cellular and molecular impact of different doses of irradiation on healthy cardiac muscle cells in vitro.
Kim JS, Choi SW, et al. (2022). International Journal of Molecular Sciences. 
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>> SLC13A5/NaCT overexpression causes disrupted white matter integrity and an autistic-like phenotype
Discover how scientists used a transgenic mouse model that overexpresses the sodium/citrate co-transporter SLC13A5 in cortical and hippocampal neurons to examine links between abnormal intracellular flux and autism spectrum disorder.
Rigby M, Orefice NS, et al. (2022). Brain Communications. 
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>> Bioelectronic assay identifies potential COVID-19 therapeutic targets
Axion’s Chief Technical Officer James Ross, PhD, describes how bioelectronic assays enable scientists to overcome limitations of traditional methods and accelerate COVID-19 drug development by targeting the viral replication process.
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>> Real-time monitoring of CAR-T cell therapy using a bioelectronic assay
Discover how Lohitash Karumbaiah, PhD, and his team at the University of Georgia are using noninvasive bioelectronic assays to quickly and efficiently characterize CAR-T cell-mediated killing of glioblastoma brain cancer in vitro.
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>> The Scientist Speaks podcast: modeling epilepsy in a dish
Evangelos Kiskinis, PhD, of Northwestern University Feinberg School of Medicine, discusses his work examining drug-resistant epilepsies using 3D patient-derived induced pluripotent stem cells.
Listen on your favorite podcast platform.

Upcoming Events

>> Innate Killer Summit
San Diego, CA / Mar 30-April 1
Stop by our booth and learn how researchers are using Maestro Z and ZHT assay systems to track NK cell-mediated cancer cell killing label-free and in real time.
>> Society of Toxicology
San Diego, CA / Mar 27-31

Visit our booth to see how Maestro research is impacting the field of toxicology and learn more about the world's most advanced MEA and impedance platform.



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