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Junctional instability in neuroepithelium and network hyperexcitability in a focal cortical dysplasia human model

Discover how researchers generated a patient-derived cortical organoid model from induced pluripotent stem cells that mimics focal cortical dysplasia hallmarks in vitro and provides new insights into pathways affecting brain development.
Avansini S, Puppo F, et al. (2021.) Brain Communications. 
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β-Asarone attenuates Aβ-induced neuronal damage in PC12 cells overexpressing APPswe by restoring autophagic flux

Scientists used the rat pheochromocytoma cell line PC12 as a model to explore whether beta-asarone—the main component of a traditional Chinese medicine for dementia—protects cells from amyloid-beta-induced injury by affecting autophagic flux.

Li Z, Ma J, et al. (2021.) Frontiers in Pharmacology. 
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Maternal bisphenol A (BPA) exposure alters cerebral cortical morphogenesis and synaptic function in mice

Researchers used a multiplatform approach to demonstrate that bisphenol A (BPA) exposure during gestation leads to abnormal cortical architecture and function in mouse offspring—an alteration that may be due to increased autophagy.

C Lee, S-A Hyun, et al. (2021.) Cerebral Cortex.
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Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma

Learn how researchers used cultured rat neurons exposed to cerebrospinal fluid from people with multiple sclerosis to identify groups of metabolites produced by gut microbiota and demonstrate their potential neurotoxic effects.
Ntranos A, Park H-J, et al. (2021.) Brain Communications.
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Customer Review

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"Quantitative data with a convenient mobile app. The Maestro Z provides a quantitative measurement of CAR-T cell-mediated cytotoxicity. The system is very easy to use, and it's powerful to see CAR-T cell killing profiles over time. The number of experiments you can run continuously with majority hands-off time is incredible. The mobile app is also great for making decisions about when to come into the lab, when to add effectors, and so on."

Heather Lin
Emory University



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