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>> Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors

Scientists generate bispecific T cell engager (BiTE)-secreting T cells and demonstrate their superior anti-tumor activity compared to a corresponding chimeric antigen receptor (CAR) version in a glioblastoma brain tumor model. 
Yin Y, Rodriguez JL, et al. (2022). Molecular Therapy. 
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>> Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1

The authors examine neuronal activity in neurofibromatosis-1-related tumor progression and reveal that suppressing neuronal hyperexcitability with the antiseizure medication lamotrigine stops tumor growth in Nf1-mutant mice.
Anastasaki C, Mo J, et al. (2022). Nature Communications. 
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>> Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction

Researchers explore the role of 4R tau in neurodegenerative disease and show that lowering tau expression rescues astrocyte function—findings that may lead to the development of novel therapeutics against disease progression.
Ezerskiy LA, Schoch KM, et al. (2022). JCI Insight. 
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>> Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury

Scientists establish the presence of BKCa channels in the plasma membranes of cardiomyocytes and show that inhibition of BKCa channels is cardioprotective against myocardial ischemia and reperfusion injury in neonatal hearts.
Sanghvi S, Szteyn K, et al. (2022). Cell Death Discovery. 
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>> Why cannabinoids might be a problem and a solution for autism spectrum disorder

Drs. Karen Litwa and Ken Soderstrom at East Carolina University’s Brody School of Medicine use a 3D cortical spheroid model to examine links between the endocannabinoid system and autism spectrum disorder.

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Upcoming Events

>> Onco Cell Therapy Summit (OCTS)
Boston, MA / June 29-30

Stop by to learn how our noninvasive, label-free Maestro and CytoSMART live-cell analysis platforms are transforming immunotherapy discovery.

Hear Axion's Chief Scientific Officer David Ferrick, PhD, present "Functional Analytics: Ensuring biological fidelity from discovery to manufacturing," Wednesday, June 29, at 3:15pm.

>> FENS Forum 2022
Paris, France / July 9-13

Discover how neuroscientists around the world are using Axion’s noninvasive in vitro assays to explore neurodevelopmental and neurodegenerative disease.


>> Gene Therapy for Neurological Disorders
Paris, France / July 11-13

Check out our booth to learn how Axion's next-generation Maestro platforms are accelerating neurological disease modeling and drug discovery.

>> Cell Therapy Potency Assay Summit
Boston, MA / July 26-27

Visit our booth to learn how scientists are using Maestro and CytoSMART live-cell analysis platforms to advance the development of cell-based therapeutics. 


Travel Awards

Axion BioSystems is proud to support researchers as they share their scientific discoveries and Maestro data at conferences around the world. Congratulations to this month's travel award winner: 

>> Hamed Salmanzadeh, University of the Pacific 


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