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Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy

Patient specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM’s) were evaluated as a preclinical in vitro model to understand the underlying mechanism of Noonan Syndrome, identify a unique disease-specific proteome signature, and evaluate a personalized therapeutic approach using the CRISPR method.
Hanses U, Kleinsorge M, et al. (2020). Circulation. 
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Regulation of dopamine-dependent transcription and cocaine action by Gadd45b

In this paper, the authors investigated the role of Gadd45b in the behavioral response to drugs of abuse and drug addiction. Using multiple tools including CRISPR and electrophysiological measurements they evaluated the dopamine-dependent epigentic regulation and cocaine reward. In vitro studies of Gadd45b knockdown decreased striatal neuron action potential burst duration only.
Zipperly ME, Sultan FA J, et al. (2020). Neuropsychopharmacology. 
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Presynaptic L-type Ca2+ channels increase glutamate release probability and excitatory strength in the hippocampus during chronic neuroinflammation

Investigation of hyperexcitability in hippocampal circuits associated with neuroinflammation in epilepsy and other neurological disorder disorders.

Giansante G, Marte A, et al. (2020). Journal of Neuroscience
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Acute in vitro effects on embryonic rat dorsal root ganglion (DRG) cultures by in silico predicted neurotoxic chemicals: Evaluations on cytotoxicity, neurite length, and neurophysiology

Rat dorsal root ganglia (DRG) were treated with neurotoxic drugs to evaluate in vitro the effects of cytotoxicity.  Four of the compounds were shown to decrease the MFR in absence of cytotoxicity.
Johnstone AFM, Mack CM, et al. (2020). Toxicology In Vitro. 
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Upcoming Events

Society for Immunotherapy of Cancer Virtual (November 9-14)

Be sure to visit our virtual booth to learn more about how the Maestro Z system is being used to evaluate killing kinetics of immune cells (e.g. CAR T or NK) at physiologically relevant effector cell to target cell ratios.


AxIS Tips

Introducing the MEA Automation Module 

Now you can automate your Maestro Pro and Edge assays with the introduction of the MEA Automation software module. The MEA Automation Module is an application programming interface (API) built into AxIS Navigator that is used for interfacing with liquid handling platforms or other systems to automate MEA experiments. Use your liquid handling robot and the MEA Automation Module to fully automate Maestro assays from start to finish, including plate preparation, media exchanges, drug dosing, moving plates in and out of the Maestro, and data acquisition/analysis.

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Customer Review

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Excellent machine, excellent company.

We are a lab studying SARS-CoV-2, so we were very pleased with how easy it was to install the Maestro Z system in our BSL3 lab and start collecting data the same day. Setting up experiments is quite straight forward with the plate map editor that allows you to design concentration response curves in a few clicks. This along with the new Maestro Z App that allows tracking of my experiments on my smartphone makes for a very nice user experience. The Maestro Z assay is very sensitive allowing us to detect virus-induced effects within 24 hours after infection, much faster than a plaque assay. We also appreciate that the machine provides kinetic results with very fine resolution allowing us to watch as the infection progresses over time. Finally, the customer support we have received from Axion has been nothing short of exceptional.

Alex Jureka
Georgia State University, USA


Maestro Z App allows tracking of my experiments on my smartphone...


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