Axion Biosystems    


Real-time monitoring of levetiracetam effect on the electrophysiology of an heterogenous human iPSC-derived neuronal cell culture using microelectrode array technology

Scientists using a neural co-culture of glutamatergic, GABAergic, and dopaminergic neurons, and astrocytes, uncover mechanisms of levetiracetam efficacy and demonstrate MEA platform as a “gold standard” for modeling complex neural network behavior.
Di Credico A, Gaggi G, et al. (2021). Biosensors.
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Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation

Researchers conducted a combination of in vitro testing and in silico simulations to explore the impact of patient-specific factors on the development of drug-induced cardiac arrhythmias related to hydroxychloroquine and azithromycin.

TeBay C, McArthur J, et al. (2021). British Journal of Pharmacology. 
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Depletion of m6A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin

The authors used YTHDC1 conditional knockout mice to expand the knowledge of post-transcriptional regulation in the development of dilated cardiomyopathy and uncover a potential new therapeutic target.

Gao S, Sun H, et al. (2021). Journal of Cellular and Molecular Medicine.
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Activation of retinal ganglion cells using a biomimetic artificial retina

Discover how scientists used bioelectronic assays to investigate a protein-based artificial retina technology that integrates the microbial rhodopsin and proton pump BR into a multilayered film that stimulates retinal neural cells.
Greco J, Wagner N, et al. (2021). Journal of Neural Engineering.
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COVID-19 Therapeutic Discovery Using a Bioelectronic Assay

Axion’s Chief Technical Officer James Ross, PhD, explains how the Maestro impedance assay can accelerate drug development for COVID-19 by enabling scientists to characterize potential inhibitors of SARS-CoV-2 replication and noninvasively assess the activity of multiple drug candidates in vitro.

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Upcoming Events

Cell Therapy Analytical Development Summit (Dec. 14-16)

Visit our booth to find out how Axion’s Maestro Z platform tracks cell proliferation, viability, morphology, immune cell-mediated killing, viral cytopathic effects, and more—all label-free and in real time.


AxIS Tips

Barrier Index in AxIS Z

Barrier Index measures the integrity of the barrier formed by the cell layer and is a ratio between the resistance at low frequency to the resistance at high frequency. An increase in Barrier Index indicates that the barrier is less leaky, whereas a decrease means the barrier is leakier. The barrier index is influenced by the junctions between cells as well as the opening of channels or pores through the cell membrane (e.g., transient receptor-mediated channel opening). When the Barrier Index Configuration is selected, Media Background, Treatment Only, Time Reference, Vehicle Correction, and Display Interval analysis options are available. Barrier Index requires that a media only control type is assigned to at least one Well Group when designing the plate map.

Customer Review

Orange Quote
Professional knowledge and drug development knowledge to simulate the human immune system and generate predictive models to identify and develop new immunotherapies to treat various human cancers, bacterial diseases and viral infections.

Rahul Nema
Nema Pathology Centre



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