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| Publications | News | Upcoming Events | AxIS Tips | Customer Review | December, 2021 |
Real-time monitoring of levetiracetam effect on the electrophysiology of an heterogenous human iPSC-derived neuronal cell culture using microelectrode array technology
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Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation
Researchers conducted a combination of in vitro testing and in silico simulations to explore the impact of patient-specific factors on the development of drug-induced cardiac arrhythmias related to hydroxychloroquine and azithromycin.
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Depletion of m6A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin
The authors used YTHDC1 conditional knockout mice to expand the knowledge of post-transcriptional regulation in the development of dilated cardiomyopathy and uncover a potential new therapeutic target.
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Activation of retinal ganglion cells using a biomimetic artificial retina
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COVID-19 Therapeutic Discovery Using a Bioelectronic Assay
Axion’s Chief Technical Officer James Ross, PhD, explains how the Maestro impedance assay can accelerate drug development for COVID-19 by enabling scientists to characterize potential inhibitors of SARS-CoV-2 replication and noninvasively assess the activity of multiple drug candidates in vitro.
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Cell Therapy Analytical Development Summit (Dec. 14-16)
Visit our booth to find out how Axion’s Maestro Z platform tracks cell proliferation, viability, morphology, immune cell-mediated killing, viral cytopathic effects, and more—all label-free and in real time.
Barrier Index in AxIS Z
Barrier Index measures the integrity of the barrier formed by the cell layer and is a ratio between the resistance at low frequency to the resistance at high frequency. An increase in Barrier Index indicates that the barrier is less leaky, whereas a decrease means the barrier is leakier. The barrier index is influenced by the junctions between cells as well as the opening of channels or pores through the cell membrane (e.g., transient receptor-mediated channel opening). When the Barrier Index Configuration is selected, Media Background, Treatment Only, Time Reference, Vehicle Correction, and Display Interval analysis options are available. Barrier Index requires that a media only control type is assigned to at least one Well Group when designing the plate map.
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Professional knowledge and drug development knowledge to simulate the human immune system and generate predictive models to identify and develop new immunotherapies to treat various human cancers, bacterial diseases and viral infections.
Rahul Nema
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