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Noninvasive multielectrode array for brain and spinal cord local field potential recordings from live zebrafish larvae

This paper describes a noninvasive multielectrode array assay using Axion’s Maestro Edge system for brain and spinal cord local field potential recordings from live zebrafish larvae.
Tomasello D and Sive H (2020). Zebrafish. 
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Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability

Researchers at the University of Alabama at Birmingham identified the BIN1 locus as a genetic risk factor in Alzheimer's disease (AD). Higher BIN1 expression induced network hyperexcitability on multielectrode arrays indicating that increasing BIN1 drives greater neuronal activity.  
Voskobiynyk Y, Roth J, et al. (2020). eLife. 
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Developmental GABA polarity switch and neuronal plasticity in bioengineered neuronal organoids

Neural organoids, recorded on Axion’s Maestro Pro MEA system, demonstrate complex network burst development after two months and evidence for long-term potentiation.

Zafeiriou MP, Bao G, et al. (2020). Nature Communications
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Repolarization instability and arrhythmia by IKr block in single human-induced pluripotent stem cell-derived cardiomyocytes and 2D monolayers

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM's) electrophysiological properties were evaluated in a Maestro MEA assay to determine their suitability for in vitro studies of pro-arrythmia markers..
Altrocchi C, de Korte T, et al. (2020). EP Europace. 
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Upcoming Events

Immuno Series UK (August 24-25)

Be sure to visit our virtual booth to learn more about how the Maestro Z system is being used to evaluate killing kinetics of immune cells (e.g. CAR T or NK) at physiologically relevant effector cell to target cell ratios.


From Stem Cells to Human Development (September 8-11)

Visit our virtual booth for a chance to talk to our representatives about how the Maestro platform can show the functional development of your stem cell-derived electrically active neurons or cardiomyocytes.


AxIS Tips

Copy Plate Map from Excel to AxIS Navigator 

AxIS Navigator makes it easy to import plate maps created in Microsoft Excel. In Excel, create a map in the plate layout where each cell represents a well on the plate and contains information in the format of “Treatment [Concentration]”. To copy the plate map, highlight the entire plate map in Excel, including the row and column headers. Then, press Ctrl+C. Select all of the wells in the Plate Map Editor in AxIS Navigator. Then, right-click and select Paste to Well(s). If you color the cells in Excel, the well colors will be copied to AxIS Navigator also. If you don’t include colors in your Excel plate map, right-click on the plate map in AxIS Navigator and select Auto Color to automatically assign unique colors to each treatment group.

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Customer Review

Orange Quote
The Maestro MEA system is extremely easy to operate and acquire data

The user-friendly software is very nice and visualizes neural activity from multiple wells in real-time, and it is intuitive. Our lab members can easily operate and smoothly conduct experiments with drug and electrical stimulations. Since the temperature and CO2 environment are well maintained, long-term continuous measurement is possible. In addition, the MEA plates delivered are well managed, and customer support is very good.

Dr Ikuro Suzuki
Tohoku Institute of Technology, Japan


Easy-to-use, high throughput electrophysiological platform.


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