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.... Publications

Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson's disease models

MicroRNA reprogramming factors and novel in vitro differentiation methodology generated functional and healthy dopamine neurons. This method presents a scalable, safe and effective method of producing autologous neurons that secrete dopamine, and exhibit typical electrophysiology.
 
Song B, Cha Y, et al. (2020). Journal of Clinical Investigation. 
 
Read the full article here. 

Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

Maestro MEA data showed that photo-release of dopamine increased cardiomyocyte beat rate.  The synthesis and application of biocompatible BODIPY-based photoprotecting amines are cleavable with red light.  These light sensitive compounds can be used to control the beating frequency of human cardiomyocytes.
 
Sitkowska K, Hoes M, et al. (2020). Chemical Communications. 
 
Read the full article here. 

Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemia-reperfusion injury

Learn how Maestro MEA was used to show how IL-4 reduces spontaneous firings and network activities of mouse primary cortical neurons.  These findings demonstrate how the IL-4 signalling may help protect the brain after injury or stroke.

Chen X, Zhang J, et al. (2020). Acta Pharmaceutica Sinica B
 
Read the full article here. 

The tumor-suppressive human circular RNA circITCH sponges miR-330-5p to ameliorate doxorubicin-induced cardiotoxicity through upregulating SIRT6, survivin and SERCA2a

Discover how Axion's MEA data helped revealed that CircITCH ameliorated DOX-induced cardiomyocyte injury.  
 
Han D, Wang Y, et al. (2020). Circulation Research. 
 
Read the full article here.
.... Upcoming Events

AACR Virtual Annual Meeting II (June 22-24)

Be sure to visit our posters online during this virtual meeting:

 
 

ISSCR Virtual Meeting (June 23-27)

Don’t miss our online posters during this virtual meeting:

MDD128 - Optimization of chronic pacing protocols for functional maturation of hiPSC-CMs, June 25th, 2pm EST
 
MDD430 - Novel methods for assessing electrophysiological function of cardiac and neural three-dimensional cell cultures with MEA technology, June 25th, 10pm EST
 
MDD299 - Multiwell microelectrode array (MEA) technology for the quantification of neuronal, synaptic, and network function for in vitro stem cell derived neuronal models, June 27th, 11am EST
 
 ...AxIS Tips
Introducing Cardiac, Neural, and Impedance Software Modules

Axion software now allows users to customize their Maestro Pro and Edge systems to meet their assay needs with the introduction of Neural, Cardiac, and Impedance software modules. The Neural Module allows users to measure electrical network behavior of neurons, including activity, synchrony, and network oscillations. The Cardiac Module enables the acquisition of the four key measures of cardiac performance: Action Potential, Field Potential, Propagation, and Contractility for cardiomyocyte applications. The Maestro Z’s impedance software is now available on Maestro Pro and Edge. The Impedance Module allows users to monitor changes in cell proliferation, viability, and cell killing over minutes or weeks, label-free and in real-time. To request a new module for your Maestro system, please request information on our website

 ... Customer Review

"Strongly Recommend"

"First of all, I like that it is very easy and simple to use, so anyone can use it without special skills. Also, various kinds of tools available that can be used to efficiently analyze the signal of the sample are very useful to me. I also liked the services, such as answering questions kindly" 

Hyunwoong Kim, Sogang University


Click here to learn more about the success of Maestro Edge users.

 

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