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BrainPhys neuronal medium optimized for imaging and optogenetics in vitro

In this paper, the authors developed a neural cell culture medium called BrainPhys Imaging Optimized. Compared to other media, BrainPhys Imaging Optimized optimally supports the electrical and synaptic activity of neurons in culture, enhances fluorescence signals, and reduces phototoxicity.
Zabolocki M, McCormack K, et al. (2020). Nature Communications. 
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An epilepsy‐associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model

The authors investigated the pathophysiological mechanism underlying the pathogenic variants in ACTL6B patients. Using patient-derived neurons they were able to show reduced protein stability, and dysregulation of target gene expression important for neuronal disease and development.  MEA recordings showed elevated electrophysiological activity in the patient-derived neurons consistent with the patient phenotype.

Ahn LY, Coatti GC, et al. (2020). Journal of Neuroscience Research. 
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Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids

The authors used the Maestro MEA system to evaluate the network activity of MECP2-KO neurons and cortical organoids to evaluate potential pharmacological treatments.

Trujillo CA, Adams JW, et al. (2020). EMBO Molecular Medicine.
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Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

The authors evaluated the effect of buprenorphine on hiPSC-derived cardiomyocytes using Maestro MEA technology to determine if there was an associated long QT prolongation.
Tran PN, Sheng J, et al. (2020). PLOS One. 
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Upcoming Events

Cell Therapy Analytical Development Summit
(December 15-17)

Visit Axion’s virtual booth to see how Axion’s Maestro Z platform is being used to test the potency of T cells label-free and in real time.


SfN Virtual Connectome 
(January 13-15)

Join us virtually at SfN online.  Discover how we can enhance your neural activity assays with the Maestro Pro and Edge MEA systems.


AxIS Tips

enable wells in software
Enabling or Disabling Wells and Electrodes

Electrodes can be disabled using the right-click menu in the Continuous Waveform Plots, Spike Plots, or Cardiac Beat Plots panels in AxIS Navigator. To disable or enable an electrode in the selected well, right click on an electrode plot and select Disable Electrode to turn it off or on. A blank plot indicates an electrode has been turned off. Alternatively, an electrode can be turned on or off by double-clicking on it in the Plate Map Editor. Wells can be turned on or off with the toggle switch under Well Information. Disabled wells appear black and disabled electrodes appear gray in the Plate Map Editor. Turning off a well or electrode will prevent it from being recorded or analyzed, reducing the file size.


Customer Review

Orange Quote
Very easy to use, has user friendly software and creates nice heat maps that are easy to interpret.

Olivia Turner
Apconix, UK


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