 |
BrainPhys neuronal medium optimized for imaging and optogenetics in vitro
| Read the paper |
An epilepsy‐associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model
The authors investigated the pathophysiological mechanism underlying the pathogenic variants in ACTL6B patients. Using patient-derived neurons they were able to show reduced protein stability, and dysregulation of target gene expression important for neuronal disease and development. MEA recordings showed elevated electrophysiological activity in the patient-derived neurons consistent with the patient phenotype.
| Read the paper |
Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids
The authors used the Maestro MEA system to evaluate the network activity of MECP2-KO neurons and cortical organoids to evaluate potential pharmacological treatments.
| Read the paper |
Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block
| Read the paper |
Cell Therapy Analytical Development Summit
(December 15-17)
Visit Axion’s virtual booth to see how Axion’s Maestro Z platform is being used to test the potency of T cells label-free and in real time.
SfN Virtual Connectome
(January 13-15)
Join us virtually at SfN online. Discover how we can enhance your neural activity assays with the Maestro Pro and Edge MEA systems.
Electrodes can be disabled using the right-click menu in the Continuous Waveform Plots, Spike Plots, or Cardiac Beat Plots panels in AxIS Navigator. To disable or enable an electrode in the selected well, right click on an electrode plot and select Disable Electrode to turn it off or on. A blank plot indicates an electrode has been turned off. Alternatively, an electrode can be turned on or off by double-clicking on it in the Plate Map Editor. Wells can be turned on or off with the toggle switch under Well Information. Disabled wells appear black and disabled electrodes appear gray in the Plate Map Editor. Turning off a well or electrode will prevent it from being recorded or analyzed, reducing the file size.
 |
Very easy to use, has user friendly software and creates nice heat maps that are easy to interpret.
Olivia Turner |
|
Follow Us: |
