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.... Travel Award
Travel Award 

Axion BioSystems Travel Award Winner: Congratulations Muhamad Mergaye 

Congratulations to Muhamad Mergaye in the Khan lab at Ohio State University, this month's Travel Award winner.  Muhamad's poster on Functional assessment of low oxygen preconditioned human iPSC-derived cardiomyocytes subjected to anoxia challenge will be presented at the 14th annual conference on Stem Cells and Biomaterials. 

To read more about Muhamad's research, click here
.... Publications
Frontiers in Immunology Journal Cover Activated bone marrow-derived macrophages eradicate Alzheimer's-related Aβ42 oligomers and protect synapses

Discover how Axion's Maestro MEA was used to assess activated macrophages as a treatment for Alzheimer's disease.   
Li S, Hayden E, et al. (2020). Frontiers in Immunology. 
Read the full article here. 
Nature communications Journal Cover Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

Learn how Maestro MEA was used to evaluate loss-of-function alleles in patient-derived cerebral organoids.
Hengel H, Lefevre Cet al. (2020). Nature Communications. 
Read the full article here. 
elife Journal Cover Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

Researchers used the Maestro MEA to understand the basis of hyperactivity in hiPSC-derived cerebrocortical neuronal cultures and cerebral organoids with AD-related mutations.  
Ghatak S, Dolatabadi N, et al. (2019). eLife. 
Read the full article here. 
Toxicological Sciences Journal Cover Effects of electrical stimulation on hiPSC-CM responses to classic ion channel blockers 

Researchers compared hiPSC-CMs in a Maestro MEA to evaluate the response to classic cardiac ion channel blockers under spontaneous and stimulated (both electrical and optogenetic pacing) beating conditions.
Wei F, Purrier M, et al. (2020). Toxicological Sciences. 
Read the full article here. 
.... Upcoming Events
SOT 2020 Alternative: submit your poster or presentation and we will send you a water bottle Don’t miss the opportunity to share your 2020 SOT presentations with your peers!

You were likely as disappointed as we were to hear that the 2020 Society of Toxicology Annual Meeting was cancelled. Don’t miss the opportunity to share your latest Maestro research with your peers.  Submit your presentations (e.g. posters; short video clips of you discussing your poster; podium presentations) and we’ll host them on our virtual conference page.

If that wasn’t enough, as a “thank you” we’ll send you one of our new Nalgene water bottles!

Developmental Neurotoxicity Conference 5 DNT5 (Apr 5-8 | Konstanz, Germany)

Visit Axion’s booth to learn how Maestro MEA assays support our understanding of how chemicals impact the developing nervous system.

Learn more about this meeting here

British Toxicology Association 2020 British Toxicology Association Annual Congress (Apr 20-22 | Cardiff, UK)

This program covers a spectrum of of toxicology studies from academia to industry and regulatory science. Posters will include a variety of Maestro MEA research and data.

Learn more about this great event here

 ... AxIS Tips
Axis Software Tips Spike Waveform Clearing in AxIS Navigator

The Spike Plots module uses output from a Spike Detector to display the spike voltage waveforms of the active well. The spike waveform plots will display a maximum of 20 spikes overlaid at once, with the brightest trace representing the most recently detected spike on that electrode. To specify how often spike waveforms are removed, right-click on the plot and select Waveform Clearing. Options include: After 1 Minute Spike, where waveforms are cleared 1 minute after they are detected, At End Of Raster, where waveforms are cleared after they no longer display in the raster plot, and Manual, where waveforms are not cleared unless Clear Spikes is selected. 

 ... Customer Review
Maestro Pro System "Very versatile and easy-to-use instrument"

"Straightforward software, easy-to-use equipment and we have obtained high-quality and reproducible results. My advice for other users is to find a good protocol to plate the cells. Once you have it, the battle is won! You will always get quality data from the Maestro Pro. Data analysis tools are extremely good, no need for a deep and solid understanding of electrophysiology. One could work with the machine and analyze the data without being an expert in electrophysiology." 

Julio Alvarez, Janssen Pharmaceuticals

Click here to learn more about the success of Maestro Pro users.


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