Spontaneous uterus contractions, which occur throughout the estrous cycle in non-pregnant and pregnant states, is a complex and dynamic physiological phenomenon . Non-pregnant myometrium exhibits different contractions at different phases of the estrus cycle in the mouse. It is crucial to understand the mechanisms that generate and modulate uterine contractility in order to be able to prevent and/or treat the problems related with the myometrium. The mechanisms by which the nonpregnant uterus initiates spontaneous contractions remain poorly understood.
Microelectrode array have been widely used for studying neural electrophysiology and communication. In this study, the authors study non-pregnant mouse uterine longitude smooth muscle electrical activity during different stages of the estrous cycle using Maestro MEA.